Scalable NMR spectroscopy

Nuclear magnetic resonance (NMR) has been celebrated for its ability to determine molecular structures and dynamics at atomic resolution, with a profound impact in organic chemistry, biochemistry, structural biology, and drug discovery. We create silicon NMR spectrometers that can execute a broad palette of multidimensional NMR spectroscopic modalities, and operate them with a superconducting magnet as well as a compact permanent magnet. The aim is to develop translational biomolecular NMR spectroscopy technologies by leveraging the size and cost economy of the silicon NMR spectrometer chips. Particular technologies of interest include: (1) high-throughput pharmaceutical screening and structural biology; (2) high-throughput metabolomics; (3) in-cell NMR; (4) correlated acquisition spectroscopy; and (5) portable NMR spectroscopy.