Biotechnology

Scalable NMR spectroscopy

Nuclear magnetic resonance (NMR) has been celebrated for its ability to determine molecular structures and dynamics at atomic resolution, with a profound impact in organic chemistry, biochemistry, structural biology, and drug discovery. We create silicon NMR spectrometers that can execute a broad palette of multidimensional NMR spectroscopic modalities, and operate them with a superconducting magnet as well as a compact permanent magnet. The aim is to develop translational biomolecular NMR spectroscopy technologies by leveraging the size and cost economy of the silicon NMR spectrometer chips. Particular technologies of interest include: (1) high-throughput pharmaceutical screening and structural biology; (2) high-throughput metabolomics; (3) in-cell NMR; (4) correlated acquisition spectroscopy; and (5) portable NMR spectroscopy.

nano & quantum materials

We investigate nanoscale, low-dimensional, and/or quantum materials, e.g., graphene and other atomic layer materials, quantum wells, wires, and dots of various constructs, and (optically-detected) spin resonance systems. We study electron transport, spin dynamics, topological order, correlated electron behavior and collective excitations, optical properties, and electrochemistry in these materials, and pursue their applications in plasmonics, photonics, spintronics, nano-biotechnology, quantum information as well as (beyond-CMOS) electronics.

Nano-bio interface

We develop nanoscale tools for biology and medicine. For example: 1) we collaborate with Professor Hongkun Park of Harvard Chemistry and Chemical Biology to create nano-bio interface arrays for neuroscience and neurotechnology; 2) we develop nano-bio-FET arrays for molecular diagnostic applications, such as whole transcript expression, drug metabolism and pharmacogenomics study, miRNA gene regulation, and targeted re-sequencing; 3) we also work on molecular diagnostics based on magnetic nano particles and nuclear magnetic resonance.

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